Description
Product Characteristics: For quantitative detection of MPP6 in serum, plasma, tissue homogenates.
Target Information: Members of the peripheral membrane-associated guanylate kinase (MAGUK) family function in tumor suppression and receptor clustering by forming multiprotein complexes containing distinct sets of transmembrane, cytoskeletal, and cytoplasmic signaling proteins. All MAGUKs contain a PDZ-SH3-GUK core and are divided into 4 subfamilies, DLG-like (see DLG1\, MIM 601014), ZO1-like (see TJP1\, MIM 601009), p55-like (see MPP1\, MIM 305360), and LIN2-like (see CASK\, MIM 300172), based on their size and the presence of additional domains. MPP6 is a member of the p55-like MAGUK subfamily (Tseng et al., 2001 [PubMed 11311936]).[supplied by OMIM, Mar 2008]